Inefficient Dialysis and Hematological Abnormalities in End-Stage Renal Disease Patients: A Cross-Sectional Study

Authors

  • Elhadi Altumi Mansour Shaeb Kastamonu University, Faculty of Science and Arts, Genetic Department, Turkey

DOI:

https://doi.org/10.61424/ijmhr.v2i1.192

Keywords:

End-stage renal disease, hemodialysis, dialysis adequacy, hematological abnormalities, anemia, Kt/V, blood urea nitrogen, serum creatinine, Mesallata Central Hospital.

Abstract

Purpose: End-stage renal disease (ESKD) necessitates hemodialysis, a life-sustaining therapy that mimics kidney function. This study aimed to investigate the association between markers of inadequate dialysis efficacy and the prevalence of hematological abnormalities in patients undergoing hemodialysis. Methods: A cross-sectional study was conducted among 61 patients receiving hemodialysis at Mesallata Central Hospital, Libya, in October 2024. Data were collected on hematological parameters (white blood cell count, hemoglobin, mean corpuscular volume, and platelet count) and laboratory markers of dialysis adequacy, including blood urea nitrogen (BUN), serum creatinine, and Kt/V values. Statistical analyses assessed correlations between dialysis adequacy markers and hematological abnormalities. Results: The findings revealed significant associations between elevated BUN and serum creatinine levels, lower Kt/V values, and the presence of anemia and thrombocytopenia. Suboptimal dialysis adequacy (Kt/V < 1.2) was observed in 67.2% of patients. Anemia was prevalent, with 75.4% of patients exhibiting low hemoglobin levels and 77% and 86.9% showing reduced mean corpuscular volume and hemoglobin levels, respectively. Elevated white blood cell counts were present in 23% of patients. Significant correlations were found between Kt/V values and serum creatinine (r = -0.68, p < 0.01) as well as hemoglobin levels (r = 0.45, p < 0.01). Conclusion: These results suggest a potential link between inadequate dialysis efficacy and hematological abnormalities in hemodialysis patients. Optimizing dialysis protocols and continuous monitoring are essential to improve patient outcomes and address these complications.

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Published

2025-01-22 — Updated on 2025-01-23

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How to Cite

Shaeb, E. A. M. (2025). Inefficient Dialysis and Hematological Abnormalities in End-Stage Renal Disease Patients: A Cross-Sectional Study. International Journal of Medical and Health Research, 2(1), 18–24. https://doi.org/10.61424/ijmhr.v2i1.192 (Original work published January 22, 2025)